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Ipca & Makers Hike Stake In Mangalam Drugs to 14% VIVEK SINHA TIMES NEWS NETWORK[ SATURDAY, NOVEMBER 11, 2006 12: AM] NEW DELHI: Mumbai-based mid-size pharma company Ipca Laboratories along with Makers Laboratories has picked up additional stake in bulk drugs and chemicals manufacturer Mangalam Drugs & Organics to take the total exposure in the company to over 14%. Interestingly, this comes at a time when one of the co-promoters of Mangalam Drugs has been diluting his equity in the company and indicated the intention to disassociate with it. When contacted by ET, Premchand Ghoda, managing director of Ipca Labs, confirmed the development. "We see it as an investment, " he said. This move is however keenly watched given the fact that as per the Indian takeover laws, acquisition of 15% stake and above in a listed company triggers a mandatory open offer for shareholders. "Earlier, we were thinking of a strategic investment but now we are reviewing our plans. At this stage we have not decided whether to increase our stake further, " said Mr Ghoda. The Mangalam Drugs' scrip has seen some hectic activity in the stock market since the time Ipca first picked a 10.26% stake, through off-market transactions from one of the co-promoters of Mangalam Drugs', Ashok Boob and his family, on October 19. It has jumped 75% in the last three weeks to close at Rs 31.3 on the BSE today. Ipca along with Makers Laboratories has acquired an additional 3.77% stake in Mangalam this week through market purchase. The anti-malarial drugs segment forms a large part of the product portfolio of both companies. Mangalam Drugs, with revenue of around Rs 100 crore in FY06, generates more than 60% of its sales from bulk drugs while the rest comes from chemical and other streams. The company is engaged in the manufacturing of bulk drugs & intermediates, speciality chemicals and disperse dye products. Incidentally, Mangalam Drugs' board has recently approved a preferential allotment to Poonawala Investment & Industries for about 4.5% stake along with warrants to the existing promoter group-- Ramniwas Dhoot. ends.
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Available to you throughout the process. If you have routine questions, you can call your provider's staff during regular office hours. Your healthcare provider will give you a number to call in case of emergency, and you should take your Medication Guide with you if you go to an emergency room or provider other than the one who prescribed your Mifeprex, so they know you are undergoing a medical abortion with Mifeprex and methotrexate.
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The safety of vitamin and mineral supplements generated a huge amount of media interest last week. Pharmacists may be wondering what advice they should give to confused consumers and which products they should stock. Pamela Mason, a pharmacist with a special interest in nutrition, reports.
When you feel ready to leave your home, it will be helpful to have put aside some things that you will need. It may be safer to keep those items at a neighbor's or a friend's house. Extra set of car keys Cash, checkbook or credit cards Driver's license and social security cards for you and your children ; , green card, passport or work permit Clothes for yourself and your children Birth certificates Children's school records Health insurance cards Court papers or court orders Lease agreements or mortgage payment book and methylcellulose.
A limited understanding of iron uptake mechanisms is available for Streptococcus pyogenes, a haemolytic human pathogen capable of using a variety of haemoproteins in addition to ferric and ferrous iron. This study characterizes a transporter named siu for streptococcal iron uptake ; , which consists of an ATP-binding protein SiuA ; , a substrate-binding protein SiuD ; , and two membrane permease subunits SiuBG ; . An siuG mutant was constructed and characterized. The mutant demonstrated growth reduction in comparison to the parent strain when grown in complex medium containing iron in the form of blood, haemoglobin or serum. Only a small reduction in the growth of the siuG mutant was observed in medium containing ferric iron. However, in iron uptake assays the siuG mutant showed a decrease of approximately 30 % in Fe3 + incorporation. Addition of 6 mM haem to the medium inhibited Fe3 + uptake by the wild-type by 76 %, while addition of protoporphyrin IX did not, suggesting that utilization of haem as an iron source is responsible for the inhibition of Fe3 + uptake. Inactivation of siuG moderately reduced the ability of haem to inhibit Fe3 + incorporation by the cells. Inactivation of siaB encoding a membrane permease of a second iron transporter ; had a similar outcome, and inactivation of both transporters had a cumulative effect. These observations implicate both the siu and sia transporters in haem utilization by Strep. pyogenes. Studies in a zebrafish infection model revealed that the siuG mutant was attenuated in both intramuscular and intraperitoneal routes of infection. Together these observations show that the siu system is an iron acquisition pathway in Strep. pyogenes that is important both in vitro and in vivo.
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Shqeme, shqemja `Tanner's sumach, Sicilian sumach' Rhus coriaria ; . According to abej [1986-1989, 2, p. 151], Alb. shqeme, from an earlier form * shqam, is to be derived from Ancient Gk. F6b": H `henbane' Hyoscyamus niger ; , which has survived in the Greek dialects of southern Italy as skjmos, samu, sama. The semantic shift is, however, quite substantial, even though both have greenish flowers which tree doesn't, though? ; . The root in Engl. sumach, which arrived via Old French from Arabic summ~q, might be just as good an etymology, in particular since both sumak and tumak are known in Alb. dialects. Dial. forms include: shkmz Kosovo ; , shkems Kosovo ; , shjeme Brzeshta LB ; , shtjemz Mat ; , shqemz in Kristoforidhi ; . Also known as dru tabaku Culli KR ; , sumak Kora, Greece ; , tumak Borocka PR ; , vrsh Delvina ; . cf. Meyer 1891, p. 410; Mitrushi 1955, p. 264; Sejdiu 1984, p. 200. Shqind, shqindi `Chian turpentine tree, Terebinth' Pistacia terebinthus ; . Loanword from Mod. Gk. F6 H, FP H `mastic tree'. Used in the Alb. dialects of Greece for the more common bafr. abej [1986-1989, 2, p. 151-152] accepts the Greek origin, but because of the initial sh-, he believes the loan to be older, either from Byzantine or Ancient Greek. Related Alb. dial. forms include: shkind Greece ; , sqin southern Italy ; , shqin Delvina ; , sqinde Konispol SR ; , shqinde Himara ; and xin Gjirokastr, Vlora ; . cf. Meyer 1891, p. 411; Mitrushi 1955, p. 258; Sejdiu 1984, p. 178. Shtog, shtogu `Common elder' Sambucus nigra ; . Most likely related to Lat. sambucus, Romanian soc, despite Meyer's objections [1891, p. 417]. Dial. form: shtok southern Albania ; . Also known as shtog i zi. cf. Mitrushi 1955, p. 318; Sejdiu 1984, p. 215. Shtogr, shtogri `Bladder nut' Staphylea pinnata ; . From an etymological point of view, shtogr is related to the root shtog q.v. ; with a suffix -r, cf. bosht-r. Other dendronyms with an -r suffix include: ashr, bafr, boshtr, bujgr, bungr, frashr, fyshtr, mshtekr, qitr, ullastr, voshtr. Also known as shtog i egr, shtogr pendor. cf. Mitrushi 1955, p. 309; Sejdiu 1984, p. 230. Shurb, shurba `Service tree, sorb apple' Sorbus domestica ; . Loanword from Lat. sorbus. Dialect of Malshova PR. Other dial. forms include: shurb. Greece ; . Commonly known as vadh qv. ; . Shurrpel, shurrpela `Buckthorn' Rhamnus fallax, Rhamnus carniolica ; . Compound of Alb. shurr `urine' and perhaps pel `mare'. Other plant names based on the root shurr `urine' include: shurrthan `Common dogwood' Cornus sanguinea ; and shurrxhakz Chelidonium majus ; . Also known as arr, pjerz, qelbin. cf. Mitrushi 1955, p. 292; Sejdiu 1984, p. 199.
N lieu of making a gift to a business associate or friend this holiday season, why not consider making a gift to support the research efforts of The Wistar Institute? Beginning in mid-November, The Wistar Institute will offer honor and memorial cards expressing your choice of holiday wishes. Contact the Development Office for more details at 215-898-3930 and metolazone.
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With the aforementioned new armamentaria in the treatment of nsclc, a suggested treatment algorithm is shown in table 2.
By the application of isotope-dilution maethods, it is now possible to make accurate estimates in vivo of fluid and electrolyte in man. In this study 57 patients were studied with the use of Na24, K42, and D, 0 as tracers. It was found that expressed as per cent of body weight, total body water was increased in patients with edema. Total body water averaged 58.6 per cent in men with cirrhosis and edema, 62.9 per cent in cardiac failure and edema, and 54.6 per cent in nonedeniatous hospitalized "controls." An increase in total body sodium was found in edematous conditions. The increase was noted with a determined per unit body weight, per unit of dry body weight, per liter of body water, or per milliequivalent of total potassium. Selective or disproportionate accumulation of sodium with heart disease beyond that associated with edema formation was not demonstrated. In all groups of patients, total exchangeable potassium was decreased below normal standards when referred to either body weight or dry body weight. Distinct differences in body composition, therefore, were found between edematous and edema-free patients. The authors, however, point out the limitations in the interpretation of these data. WAIFE and micafungin.
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2-5 mg kg PO three times per day dose by 50% when start hydrochl ; 1-2 mg kg PO twice per day 2-4 mg kg PO twice per day start K + suppl when starting this drug ; 0.5 mg kg PO twice per day 0.2 mg m2 PO twice per day and midodrine.
Products or services that are new to market or have no significant history of advertising. It has been traditionally recognised that the effects of advertising can be at their most powerful and dramatic when a new product or service is launched. It is in these cases that advertising is especially efficient at making people aware of a new product or brand, acting as the catalyst to make them want to try it. However, a successful new product launch is not necessarily proof that its advertising was effective. A competent new product or concept, with efficient distribution, will achieve certain levels of success without any advertising. The judges will be interested in cases where advertising not only gained initial interest and trial, but also laid the foundations for longer-term brand success by creating a distinctive positioning or an emotional bond with the customer. The jury will also be particularly focused on the proofs underpinning the campaign claims. The launch campaign must have commenced during the period June 30th 2004 to July 31st 2006.
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DRUGS WHICH MAY CAUSE DISCOLORATION OF THE URINE: Therapeutic Category Analgesics urinary ; Antibacterial agents Color Imparted To the Urine Orange to orange-red Orange-yellow in alkaline urine ; Discoloration No specific effect ; Rust yellow or brownish Anticoagulants Anticonvulsants Antidepressants Antidote to cyanide poisoning Antiprotozoal agents Orange in alkaline urine ; , pink or red to red-brown Pink or red to red-brown Blue-green Blue or green Brown to black Rust yellow or brown Drug s ; Responsible ethoxazene Serenium ; phenazopyridine Pyridium ; salicylazosulfapyridine Azulfidine ; p-aminosalicylic acid and derivatives sulfonamides nitrofurantoin and derivatives, e.g. furazolidone Furoxone ; indanedione derivatives e.g. anisindione Hedulin ; diphenylhydantoin Dilantin ; phensuximide Milontin ; amitriptyline Elavil ; methylene blue quinine and derivatives pamaquine naphthoate Plasmochin ; primaquine chloroquine Aralen ; quinacrine Atabrine ; metronidazole Flagyl ; triamterene Dyrenium ; tolonium Blutene ; iron-sorbitolcitric acid complex Jectofer ; cascara; rhubarb 1, 8- dihydroxyanthraquinone emodin in alkaline urine ; phenolphthalein chlorzaxazone Paraflex ; methocarbamol Robaxin ; Phenothiazines riboflavin and mifeprex.
Levy JE, Jin O, Fujiwara Y, Kuo F & Andrews NC 1999 ; Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nature Genet 21: 396399. Liao SY & Stanbridge EJ 1996 ; Expression of the MN antigen in cervical Papanicolau smears is an diagnostic biomarker of cervical dysplasia. Cancer Epidemiol Biomar Prev 5: 549557. Liao SY, Brewer C, Zvada J, Pastorek J, Pastorekov S, Manetta A, Bermann ML, DiSaia PJ & Stanbridge EJ 1994 ; Identification of the MN antigen as a diagnostic biomarker of cervical intraepithelial squamous and glandular neoplasia and cervical carcinomas. J Pathol 145: 598 609. Lieskovsk J, Kaluzov M, Opavsk R, Kaluz S, Pastorek J, Kettmann R & Pastorekov S 1998 ; Up-regulation of p53 by antisense expression of HPV18E6 oncogene does not influence the level of MN CA tumor-associated protein in HeLa cervical carcinoma cells. Int J Oncol 13: 1081 1086. Lindskog S & Coleman JE 1973 ; The catalytic mechanism of carbonic anhydrase. Proc Natl Acad Sci U S A 70: 25052508. Lindskog S 1960 ; Purification and properties of bovine erythrocyte carbonic anhydrase. Biochim Biophys Acta 39: 218226. Lindskog S 1982 ; Carbonic anhydrase. In: Eichhorn GL & Marzilli L eds ; Advances in Inorganic Biochemistry, Vol. 4. Elsevier North Holland, New York: 115170. Lindskog S 1997 ; Structure and mechanism of carbonic anhydrase. Pharmacol ther 71: 120. Lindskog S, Engberg P, Forsman C, Ibrahim SA, Jonsson B-H, Simonsson I & Tibell L 1984 ; Kinetics and mechanism of carbonic anhydrase isoenzymes. Ann NY Acad Sci 429: 6175. Ling B, Bergenhem NCH, Dogson SJ, Forster RE & Tashian RE 1994 ; Determination of mRNA levels for six carbonic anhydrase isozymes in rat lung. Isozyme Bull 28: 32. Lipkin M 1971 ; Proliferation and differentiation of normal and neoplastic cells in the colon of man. Cancer 28: 38. Lipkin M 1985 ; Growth and development of gastrointestinal cells. Annu Rev Physiol 47: 175197. Loo DT & Rillema JR 1998 ; Measurement of cell death. Methods Cell Biol 57: 25164. Lopata MA, Cleveland DW & SollnerWebb B 1984 ; High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment. Nucleic Acids Res 12: 57075717. Lovejoy DA, Hewett-Emmett D, Porter CA, Cepoi D, Sheffield A, Vale WW & Tashian RE 1998 ; Evolutionarily conserved, "acatalytic" carbonic anhydrase-related protein XI contains a sequence motif present in the neuropeptide sauvagine: the human CA-RP XI gene CA11 ; is embedded between the secretor gene cluster and the DBP gene at 19q13.3. Genomics 54: 484493. Luthman H & Magnusson G 1983 ; High efficiency polyoma DNA transfection of chloroquine treated cells. Nucleic Acids Res 11: 12951308. Lnnerholm G, Selking & Wistrand PJ 1985 ; Amount and distribution of carbonic anhydrases CA I and CA II in the gastrointestinal tract. Gastroenterology 88: 11511161. Macrae FA & Young GP 1999 ; Neoplastic and Nonneoplastic Polyps of the Colon and Rectum. In: Yamada T, Alpers DH, Laine L, Owyang C & Powell DW eds ; Textbook of Gastroenterology. Lippincott Williams & Wilkins, Philadelphia, p 19651994. Maeda T, Adachi E, Kajiyama K, Sugimachi K & Tsuneyoshi M 1995 ; Combined hepatocelluar and cholangiocarcinoma: Proposed criteria according to cytokeratin expression and analysis of clinicopathologic features. Human Pathol 26: 956964. Mann T & Keilin D 1940 ; Nature, Lond 1946: 164. Maren TH 1967 ; Carbonic anhydrase: chemistry, physiology, and inhibition. Physiol Rev 47: 595 781. Maren TH 1977 ; Use of inhibitors in physiologiacal studies of carbonic anhydrase. J Physiol 232: F291F297 and methotrexate.
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ICON Health Publications has released The Official Patient's Sourcebook on Primary Biliary Cirrhosis, a comprehensive manual for anyone interested in self-directed research. Fully referenced with ample Internet listings and glossary. From the Press Release : "This sourcebook has been created for patients who have decided to make and mifepristone.
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